Lysine Sodium alginate Conjugate as controlled drug delivery vehicles for 5-Fluorouracil nanopariculate sysytem

• Ruchi Gaikwad*

Abstract

Nanomedicine can achieve tumor with spongy vasculature nearby the tumors by the enhanced permeability effect, so, the ligands inculcated at the plane of nanocarriers permit active targeting by requisite the receptors over-expressed by cancer cells or angiogenic endothilial cells. The objective of present work is development of carrier system of lysine with sodium alginate by chemical reaction. The developed carrier system utilize for formulate new colloidal drug carrier as nanoparticles (NPs) with 5-fluorouracil anticancer drug. The gelation or interlinkage of carrier system of sodium alginate with lysine display higher uptake in tumor tissue, as the scale of tumor increases, the uptake of this amino acid may also increases. The nanoparticles formulations evaluated diverse physicochemical parameters including particle size, drug loading capability, in vitro characteristics. Ionic gelation approach was used for the preparation of l-lysine conjugated sodium alginate nanoparticles due to the fact this system is non-poisonous, organic solvent free, handy and controllable. Ionic gelation approach is primarily based on the ionic interactions among the definitely charged primary amino group of the l-lysine conjugated sodium alginate and the negatively charged ions of the poly anion, including calcium chloride. These are the more extensively used ionic cross –linking agent due to its non- toxic and multivalent residences. This physical cross linking approach not only ignore the use of chemical cross-linking agents and emulsifying agents which are frequently toxic to organisms, but also avert the possibility of destruction to drugs, particularly biological agents.

Keywords

Sodium alginate,5-Fluorouracil,Nanoparticles,Lysine

Ahead of Print Date : 2024-03-24