The role of bioisosterism in modern drug design: Current applications and challenges

• Author Details:   
• Nancy Sharma
• Anand Singh Chauhan ^*
• Vinay Jain

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Bioisosterism is a crucial strategy in modern drug design that involves the replacement of one functional group with another possessing similar physical and chemical properties to enhance drug efficacy, reduce toxicity, and improve pharmacokinetic properties. This approach has been instrumental in the development of novel drugs with better target selectivity and improved pharmacodynamics. The present review highlights the fundamental principles of bioisosterism, its applications in medicinal chemistry, and its role in addressing drug design challenges. Additionally, we discuss recent advancements, computational approaches, and future perspectives of bioisosterism in pharmaceutical research.

Keywords: Bioisosterism, Drug design, Pharmacokinetics, Pharmacodynamics, Medicinal chemistry, Computational chemistry.