Synthesis, insilico characterization and antibacterial activity of 1,2,4-Triazine derivatives

• Author Details:   
• M. Jerubin Welsingh ^*
• S. Indira

Triazines are heterocyclic compounds having three hetero atoms. Triazines are of three isomeric types. They being 1,2,3-triazine , 1,2,4-triazine , and 1,3,5-triazine. The 1,3,5-triazine is also called as s-triazine (symmetrical triazine). They have significant interest due to their diverse biological activity, especially antibacterial properties.

This work focuses on the synthesis of 1,2,4-triazines using chemical methods, analysing their physical properties like Infrared Spectra, partition coefficient, Topical polar surface area, Hydrogen bond donors and acceptors, and process capability index. The antibacterial activity of these compounds against gram +ive and -ive bacteria using disc diffusion technique in Nutrient agar media is also studied.