Preparation and evaluation of a polyherbal cream for treatment of acne vulgaris

• Author Details:   
• X. Fathimagrace ^*
• A. Janani
• S. Reshma

The human skin condition known as acne vulgaris, or just acne, is characterised by scaly, red skin (seborrhoea), pimples, big papules (nodules), pinheads (papules), blackheads and whiteheads (Comedones), and scars. Skin with dense sebaceous follicles, such as the face, chest, and back, is affected by acne. The natural extracts of guava leaves (Psidium guajava), ginger rhizome (Zingiber officinale), and lemon (Citrus limon), aimed at the effective treatment of acne vulgaris. These herbal ingredients were selected for their well-documented antibacterial, anti-inflammatory, antioxidant, and astringent properties, making them suitable candidates for acne management. The cream was prepared using a suitable w/o emulsion base, ensuring optimal consistency and stability. Comprehensive evaluation parameters were performed, including physical appearance, pH determination, viscosity measurement, spreadability, and stability studies under different storage conditions. Additionally, the formulation was assessed for skin irritancy through patch testing, and washability to ensure user convenience. The results demonstrated that the polyherbal cream exhibited desirable physicochemical properties, excellent spreadability, acceptable pH, and good stability over time, with no signs of phase separation. Importantly, the irritancy studies confirmed the cream to be safe and non-irritant for topical application. The combined therapeutic potential of guava, ginger, and lemon extracts in the cream formulation suggests promising efficacy in managing acne vulgaris, offering a natural, safe, and effective alternative to conventional treatments