- Visibility 220 Views
- Downloads 197 Downloads
- Permissions
- DOI 10.18231/j.ctppc.v.7.i.3.5
-
CrossMark
Preparation and evaluation of a polyherbal cream for treatment of acne vulgaris
- Author Details:
-
X. Fathimagrace *
-
A. Janani
-
S. Reshma
X. Fathimagrace *
S. Reshma
The human skin condition known as acne vulgaris, or just acne, is characterised by scaly, red skin (seborrhoea), pimples, big papules (nodules), pinheads (papules), blackheads and whiteheads (Comedones), and scars. Skin with dense sebaceous follicles, such as the face, chest, and back, is affected by acne. The natural extracts of guava leaves (Psidium guajava), ginger rhizome (Zingiber officinale), and lemon (Citrus limon), aimed at the effective treatment of acne vulgaris. These herbal ingredients were selected for their well-documented antibacterial, anti-inflammatory, antioxidant, and astringent properties, making them suitable candidates for acne management. The cream was prepared using a suitable w/o emulsion base, ensuring optimal consistency and stability. Comprehensive evaluation parameters were performed, including physical appearance, pH determination, viscosity measurement, spreadability, and stability studies under different storage conditions. Additionally, the formulation was assessed for skin irritancy through patch testing, and washability to ensure user convenience. The results demonstrated that the polyherbal cream exhibited desirable physicochemical properties, excellent spreadability, acceptable pH, and good stability over time, with no signs of phase separation. Importantly, the irritancy studies confirmed the cream to be safe and non-irritant for topical application. The combined therapeutic potential of guava, ginger, and lemon extracts in the cream formulation suggests promising efficacy in managing acne vulgaris, offering a natural, safe, and effective alternative to conventional treatments
References
- Halla N, Fernandes I, Heleno S, Costa P, Boucherit-Otmani Z, Boucherit K, et al. Cosmetics Preservation: A Review on Present Strategies. Molecules. 2018;23(7):1571.
- Varghese JV, Krishnapriya EP, Megha H, Mubashira PM, Jose R, Shana PK. A review on formulation and evaluation of polyherbal antifungal cream. Int J Creat Res Thoughts. 2022;10(4):a795–800
- Sawant A, Kamath S, KG H, Kulyadi GP. Solid-in-Oil-in-Water Emulsion: An Innovative Paradigm to Improve Drug Stability and Biological Activity. AAPS PharmSci Tech. 2021;22(5):199.
- Leung AK, Barankin B, Lam JM, Leong KF, Hon KL. Dermatology: how to manage acne vulgaris. Drugs in Context. 2021;10:2021–86
- Katz M, Poulsen BJ. Absorption of drugs through the skin, in, Brodie BB, Gillette J, (eds.) Handbook of Experimental Pharmacology New York: Springer-Verlag, 1971;28:103.
- Proksch E, Brandner JM, Jensen JM. The skin: an indispensable barrier. Experimental Dermatol. 2008;17(12):1063–7.
- Bungau AF, Radu AF, Bungau SG, Vesa CM, Tit DM, Purza AL. et al. Emerging Insights into the Applicability of Essential Oils in the Management of Acne Vulgaris. Molecules. 2023;28(17):6395.
- Rousselle, P.; Braye, F.; Dayan, G. Re-epithelialization of adult skin wounds: Cellular mechanisms and therapeutic strategies. Adv Drug Deliv Rev. 2019,146:344–65
- Khan ZJ, Kori A, Patil SM. A review on polyherbal cream. Int J Novel Res Dev. 2023 May;8(5):669–76.
- Uddandu Saheb SK, Reddy AP, Rajitha K, Sravani B, Vanitha B. Formulation and evaluation of cream from naturally containing plant extracts. World J Pharm Pharm Sci. 2018;7(9):851-62.
- Sonalkar MY, Nitave SA. Formulation and evaluation of polyherbal cosmetic cream. World J Pharm Pharm Sci. 2016;5(2):772-9.