---

Polyphenols: The interactions with CYP isoenzymes and effect on pharmacokinetics of drugs

---

Review Article

Author Details : Bhamre Vaibhav G., Deore Pranjal D., Amrutkar Rakesh D, Patil Vinod R.

Volume : 4, Issue : 1, Year : 2022

Article Page : 13-23

https://doi.org/10.18231/j.ctppc.2022.004

Suggest article by email

Get Permission

---

Abstract

Recent clinical studies demonstrated that certain natural polyphenols like flavonoids present in dietary supplements modify the pharmacokinetics of some co-administered drugs. Number of herbal remedies interact selectively with different CYP isoenzymes and hence alter CYP- mediated drug metabolism and pharmacokinetics. Drug-polyphenol interaction may alter drug bio availability through altered absorption, distribution and metabolism. There is need to collect clinical evidences to support whether the effect of drugs and polyphenols co-administration rather than relying on in-vitro experiments or animal studies. Herbal drugs containing variety of polyphenols interact with CYP enzymes leading to either induction or inhibition of CYPs which alters the pharmacokinetic parameters of their respective substrate drugs. This information will be helpful for physicians and pharmacists to alleviate risks associated with polyphenolic remedies as well as to realize the benefits of alternative medicine.

Keywords: Polyphenols, CYP 450 isoenzymes, Pharmacokinetics

How to cite : Bhamre Vaibhav G., Deore Pranjal D., Amrutkar Rakesh D, Patil Vinod R., Polyphenols: The interactions with CYP isoenzymes and effect on pharmacokinetics of drugs. Curr Trends Pharm Pharm Chem 2022;4(1):13-23

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.