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Synthesis and evaluation of 6-Fluoro benzothiazole substituted quinazolinones

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Original Article

Author Details : P. Niharika*, J Risy Namratha, N. Sunitha, S. Manohar Babu

Volume : 4, Issue : 1, Year : 2022

Article Page : 35-40

https://doi.org/10.18231/j.ctppc.2022.007

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Abstract

Purpose: The present work was hypothesized to synthesize Benzothiazole substituted diethyl amino Quinazolinone derivatives and evaluate their antimicrobial activity.
Materials and Methods: Quinazolinones were synthesized from condensation of 2-amino benzothiazole, anthranilic acid and acetic anhydride further followed by condensation with formaldehyde and diethyl amine. Antimicrobial activity was evaluated by agar disc diffusion using organisms and anti-inflammatory and antioxidant activies were studied using albumin denaturation and hydrogen peroxide radical scavenging methods.
Results: The structures of the synthesized Quinazolinone derivatives were confirmed by spectral analysis, such as IR, H-NMR and among the derivatives screened, the compounds 4d, 4f 4g, 4h have appreciable antimicrobial activity compared to standards. The compounds (4a-4h) have least anti-inflammatory activity while compound 4g have significant antioxidant activity as that of positive control.

Keywords: 2­ Aminobenzothiazole, Quinazolinone, Antimicrobial activity, Anti­inflammatory activity, Antioxidant activity

How to cite : Niharika P, Namratha J R, Sunitha N, Babu S M, Synthesis and evaluation of 6-Fluoro benzothiazole substituted quinazolinones. Curr Trends Pharm Pharm Chem 2022;4(1):35-40

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