---

Assessment of ethanol leaf extract from urtica dioica for in vitro Anti-Helminthic properties

---

Original Article

Author Details : K. Sivaji*, V. Lavanya, SK. Sharmila, D. Abhishek, G Yuvaraju, M. Vimala Jyothi, N. Divya Mounika, P. Ramu, P. Gayatri

Volume : 6, Issue : 2, Year : 2024

Article Page : 45-55

https://doi.org/10.18231/j.ctppc.2024.014

Suggest article by email

Get Permission

---

Abstract

Helminthic infections continue to be a significant public health concern worldwide, particularly in regions with poor sanitation and limited access to healthcare. With the increasing prevalence of drug resistance among helminths, there is a pressing need for alternative treatments derived from natural sources. Urtica dioica, commonly known as stinging nettle, has been traditionally used for various medicinal purposes, including its purported anthelmintic properties. This study aimed to evaluate the in vitro anti-helminthic activity of ethanol leaf extract of Urtica dioica against helminth parasites. Fresh leaves of Urtica dioica were collected, dried, and powdered. The ethanol leaf extract was prepared using standard extraction methods. Various concentrations of the extract were tested against helminth parasites using established in vitro assays. The efficacy of the extract was determined by assessing parameters such as paralysis and mortality of the parasites. Preliminary findings indicate that the ethanol leaf extract of urtica dioica possesses significant anti-helminthic activity against the tested parasites. The extract exhibited dose-dependent paralysis and mortality of the helminths, with higher concentrations demonstrating greater efficacy. These results suggest the potential of Urtica dioica as a natural source of anthelmintic agents. Further studies are warranted to elucidate the specific bioactive compounds responsible for the observed anti-helminthic activity and to evaluate the safety and efficacy of Urtica dioica extract in vivo. Additionally, investigations into the underlying mechanisms of action and potential synergistic effects with conventional anthelmintic drugs may provide valuable insights for the development of novel therapeutic interventions against helminthic infections. The study results when compared to standard drug of fenbendazole, ethanolic extract of Urtica dioica possess a good significant anti-helmentic activity compared to standard drug of fenbendazole.

Keywords: Helminthic, Prevalence, Urtica dioica, Fenbendazole, Therapeutic interventions, Synergistic effects, Parasites, Mortality

How to cite : Sivaji K, Lavanya V, Sharmila S, Abhishek D, Yuvaraju G, Jyothi M V, Mounika N D, Ramu P, Gayatri P, Assessment of ethanol leaf extract from urtica dioica for in vitro Anti-Helminthic properties. Curr Trends Pharm Pharm Chem 2024;6(2):45-55

This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.