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Phytochemical screening and biological evaluation activity of hibiscus mutabilis leaves extract

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Review Article

Author Details : Shivani Rajhans*, Parveen Kumar

Volume : 6, Issue : 4, Year : 2024

Article Page : 130-133

https://doi.org/10.18231/j.ctppc.2024.028

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Abstract

Hibiscus Mutabilis is reported for bioactive constituent. A quantitative assessment of antimicrobial activities was carried out by determining the minimum inhibitory and microbicidal concentrations (MICs and MMCs) of the various solvent extracts like 70% ethanol, acetone and ethyl acetate against some selected bacteria such as two Gram positive bacteria Bacillus subtilis, Staphylococcus aureus and two Gram negative bacteria Escherichia coli, Pseudomonas. On treating the extract of Hibiscus Mutabilis flower leave with different pH it was found that antimicrobial activity was increasing on increasing pH. From our study, we can conclude that ethanol extract has more prevailing and sustainable antibiotic properties than other solvents extrac. Preliminary phytochemical screening of Hibiscus Mutabilis showed the presence of alkaloids, glycosides, steroids, phenols, tannins, flavonoids and saponins in the crude drug. Medicinal plants pharmaceuticals, cosmetics, and nutraceuticals. Broad variety of compounds found in treats both chronic and infectious disorders. Both industrialized and developing countries, fungus infections mortality. This is caused by immunocompromised people living longer lives, using immunosuppressive drugs, and taking antibiotics for a long period of time. The emergence of antifungal resistance in micro-organisms has major consequences for infection control. These antifungal drugs also target cells in mammals, which may cause toxicity or undesirable medication interactions. Ketoconazole is an antifungal medication treats superficial and deep-seated infections. It results in low efficacy, toxicity, nausea, abdominal pain, and itching in immunocompromised patients. As a result, the development of innovative antifungal is critical. Several species of plant phytochemistry has revealed that phytochemicals may be a more effective source of therapy than synthetically generated drugs. Since the beginning of utilized for medicinal purposes. For ages, traditional remedies based used. As a result, one method for discovering antimicrobial compounds has been to evaluate plant extracts. Individuals and communities benefit greatly from medicinal plants. This significance stems from their chemical composition, they perform a certain physiological. Bioactive materials like flavonoids, phenolic compounds, tannins, and alkaloids, which are some of the more significant ones. Flavonoids have hepatoprotective, antithrombotic, antiviral, anti-inflammatory, anti-allergic, and anticarcinogenic properties. Alkaloids offer numerous advantageous advantages, including anti-hypertensive and anti-tumor properties. Caffeine, quinine, nicotine, artemisinin, cholchicine, and amblyopia are all alkaloid-based medications. Corilagin and geraniin are tannins that have anti-human immunodeficiency syndrome action by blocking reverse transcriptase. In immunocompromised people, pathogen caused by fungi is the serious cause of illness and mortality.

Keywords: Hibiscus mutabilis, Staphylococcus aureus, Microbicidal concentrations

How to cite : Rajhans S, Kumar P, Phytochemical screening and biological evaluation activity of hibiscus mutabilis leaves extract. Curr Trends Pharm Pharm Chem 2024;6(4):130-133

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