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Formulation and evaluation of pazopanib-loaded PLGA nanoparticles for enhanced bioavailability and sustained release in cancer chemotherapy

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Original Article

Author Details : V.N. Shrikhande, Hemantkumar J Dhongade, Sandip B. Sapkal*, Mangesh A. Mapari, Akhil N. Gandhi, Gauri R. Laddhad

Volume : 6, Issue : 4, Year : 2024

Article Page : 176-179

https://doi.org/10.18231/j.ctppc.2024.033

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Abstract

The objective of this study was to develop and characterize a Nano formulation of Pazopanib using poly(DL-lactide-co-glycolide) (PLGA) for improved bioavailability and reduced systemic toxicity. Pazopanib, a tyrosine kinase inhibitor used in the treatment of renal cell carcinoma and soft tissue sarcoma, exhibits limited solubility and bioavailability, restricting its clinical efficacy. We employed an oil-in-water (o/w) emulsion solvent evaporation technique to prepare Pazopanib-loaded PLGA nanoparticles. Various formulations were optimized by adjusting the drug-to-polymer ratio, yielding spherical nanoparticles with an average size of 135 nm and a low polydispersity index, as confirmed by dynamic light scattering and transmission electron microscopy. The nanoparticles demonstrated a high entrapment efficiency of 33.9 ± 2.5% and a zeta potential of -20.12 mV, indicating good colloidal stability. Fourier transform infrared spectroscopy confirmed the compatibility of Pazopanib with PLGA and other excipients. The in vitro drug release studies revealed a sustained release profile over 7 days, contrasting with the rapid release from the free drug solution. These findings suggest that the developed PLGA-based nanoparticulate system could potentially enhance the therapeutic efficacy of Pazopanib by increasing its bioavailability and ensuring controlled release, thus offering a promising approach for cancer chemotherapy.

Keywords: PLGA, DMSO, Transmission electron microscopy (TEM)

How to cite : Shrikhande V, Dhongade H J, Sapkal S B, Mapari M A, Gandhi A N, Laddhad G R, Formulation and evaluation of pazopanib-loaded PLGA nanoparticles for enhanced bioavailability and sustained release in cancer chemotherapy. Curr Trends Pharm Pharm Chem 2024;6(4):176-179

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