Current Trends in Pharmacy and Pharmaceutical Chemistry

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Current Trends in Pharmacy and Pharmaceutical Chemistry is the official Journal of Ateos Foundation of Science Education and Research, hosted and Managed IP Innovative Publications Pvt. Ltd, New Delhi, India. Current Trends in Pharmacy and Pharmaceutical Chemistry is an open access, peer-reviewed quarterly international journal publishing since 2019 and is published under auspices of the Ateos Foundation of Science Education and Research. It aims to uplift researchers, scholars, academicians, and professionals in all academic and scientific disciplines. more...

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Get Permission Nerkar and Nagarkar: Ethnopharmacology


Introduction

Traditional medicine has been practiced for centuries in many parts of the world and has greatly influenced the development of modern medicine. Ethnopharmacology is the study of the traditional use of plants and other natural substances for medicinal purposes. This involves identifying, documenting and analyzing the knowledge and practices of traditional healers and communities related to the use of medicinal plants. The goal of ethnopharmacology is to evaluate the potential of traditional medicines in the treatment of various diseases and conditions and to find new sources of bioactive compounds for drug development. Ethnopharmacology research has received increasing attention in recent years because it offers a unique opportunity to discover new drugs and confirm the safety and efficacy of traditional drugs. However, the study of traditional medicines presents many challenges, including the lack of standardization of plant materials, the need for rigorous scientific testing, and the ethical and cultural considerations of working with indigenous peoples. Despite these challenges, ethanol pharmacology has proven to be a promising area of ​​research, with many examples of successful traditional medicinal applications in modern medicine.

Ethnopharmacology in Ayurveda

Ayurveda is an ancient traditional Indian medicine that has been practiced for over 5,000 years. It is based on the principles of balance and harmony of body, mind and spirit and focuses on the use of natural remedies including herbs, minerals and animal products. Ayurvedic medicine has a rich history of using herbal medicines to treat various ailments and diseases and is an excellent example of the practice of Ethnopharmacology. Ayurvedic texts such as Charaka Samhita and Sushruta Samhita describe the use of hundreds of plants for medicinal purposes. These texts also provide detailed information on the preparation and administration of Ayurvedic medicines. Modern research has confirmed many traditional uses of Ayurvedic plants and identified new uses. For example, turmeric, a widely used Ayurvedic herb, has been found to have anti-inflammatory and antioxidant properties and is being studied for its potential in the treatment of Alzheimer's disease, arthritis and cancer. Despite the potential benefits of Ayurvedic medicine, there are also concerns about the safety and effectiveness of some medications, especially when used in combination with other medications. Therefore, it is important to conduct rigorous scientific research on Ayurvedic medicines to determine their safety and efficacy and ensure their responsible and effective use. Overall, the study of Ayurvedic ethnopharmacology provides a valuable source of information for drug discovery and development and highlights the importance of integrating traditional medicinal practices into modern health systems.

Ayurveda: The philosophical basis

Ayurveda is an ancient science of life with a strong philosophical basis. "Ayu" means life and "Veda" means science. Although there is no firm evidence of its exact origin, the Vedic period in Indian philosophy goes back more than 5,000 years. The classics of Ayurveda are the internal medicine textbook Charak Samhita and the surgical book Sushrut Samhita 25. Ayurvedic philosophy firmly believes that man is a microcosm of nature and that all the five basic elements of nature are present in him. The original philosophical basis of Ayurveda is Sankhya, which means knowing the truth. Sankhya is a philosophy of creation and is based on the 24 principles or elements of the universe and the feminine principle of Prakruti and the feminine principle of Purusha, together they develop Mahadi-Universal Intelligence. Its first manifestation is Ahamkar or Ego, which further manifests itself in the five basic principles or Panchamahabhoota. Ayurvedic philosophy built on this concept and developed it further. Some of the basics of Ayurvedic philosophy are described below:

The five basic elements of nature are called Panch (five) Maha (great) Bhootas (elements). These Panchamahabootas include: Earth (Pruthvi), Water (Aap), Fire (Tejas), Air (Vayu) and Ether (Akash).

The earth element is associated with smell, water with taste, fire with sight, air with touch and ether with hearing. Thus, these five elements are connected to the five sense organs: ear, tongue, eye, skin and nose.

These five elements in various permutations and combinations make up all living organisms, including humans. Therefore, each person has his own nature, which is represented in the form of his Prakruti or constitution - something like a genetic makeup determined at birth.

The five basic principles or Panchamahabhootas in the human body and their combined relationship determine the constitution or Prakruti of that individual and are represented in the Tri-Dosha or three humors namely Vata (Air and Ether), Pitta (Fire and Water) and Kapha. Water and Earth). Water dominates the overall structure of the human body because it is part of the Kapha and Pitta structure. There are three main structures, seven types of secondary structures and many subtle combinations of Vata, Pitta, Kapha (VPK) depending on individual relationships.

According to Ayurvedic principles, an individual is born with a specific prakruti that remains unchanged throughout life, quite similar to a genome. However, the combination of key elements that control the body's pathophysiological changes can alter its response due to various causal factors, including diet, environment, lifestyle, infection, etc. Disease prevention, health promotion or Ayurvedic therapy revolve around strategies to restore the original balance of the basic elements through the manipulation of materials and methods to eliminate Tri-Dosha imbalances and achieve the original stable structure.

The five basic elements of nature are called Panch (five) Maha (great) Bhootas (elements). These Panchamahabootas include: Earth (Pruthvi), Water (Aap), Fire (Tejas), Air (Vayu) and Ether (Akash). The earth element is associated with smell, water with taste, fire with sight, air with touch and ether with hearing. Thus, these five elements are connected to the five sense organs: ear, tongue, eye, skin and nose. These five elements in various permutations and combinations make up all living organisms, including humans. Therefore, each person has his own nature, which is represented in the form of his Prakruti or constitution - something like a genetic makeup determined at birth. The five basic principles or Panchamahabhootas in the human body and their combined relationship determine the constitution or Prakruti of that individual and are represented in the Tri-Dosha or three humors namely Vata (Air and Ether), Pitta (Fire and Water) and Kapha. Water and Earth). Water dominates the overall structure of the human body because it is part of the Kapha and Pitta structure. There are three main structures, seven types of secondary structures and many subtle combinations of Vata, Pitta, Kapha (VPK) depending on individual relationships. According to Ayurvedic principles, an individual is born with a specific prakruti that remains unchanged throughout life, quite similar to a genome. However, the combination of key elements that control the body's pathophysiological changes can alter its response due to various causal factors, including diet, environment, lifestyle, infection, etc. Disease prevention, health promotion or Ayurvedic therapy revolve around strategies to restore the original balance of the basic elements through the manipulation of materials and methods to eliminate Tri-Dosha imbalances and achieve the original stable structure.6.1.1 Five basic elements of nature are called as Panch (five) Maha (great) Bhootas (elements). These Panchamahaboota include: Earth (Pruthvi), Water (Aap), Fire (Tejas), Air (Vayu) and Ether (Akash).

Earth element relates to sense of smell, Water relates to taste, Fire relates to vision, Air relates to touch and Ether relates to hearing. Thus these five elements are connected with five sensory organs: ear, tongue, eye, skin and nose respectively.

These five elements in various permutations and combination proportions form all living bodies including the human. Therefore every human being has its own character presented in form of its Prakruti or Constitution – some thing like a genetic structure determined at the time of birth.

The five basic principles or Panchamahabhoota in the human body and their combination proportions determine the constitution or Prakruti of that individual and is presented in form of Tri-Doshas or three humors namely Vata (Air and Ether), Pitta (Fire and Water) and Kapha (Water and Earth). Water predominates in the overall constitution of human body as it is part of Kapha and Pitta constitution. There are three main constitutions, seven types of secondary and many subtle combinations of Vata, Pitta, Kapha (VPK) depending on the individual proportions.

As per the Ayurvedic principles, an individual is born with a definite Prakruti which remains unaltered throughout the life span quite similar to the genome. However, the combination of the basic elements that govern patho-physiological changes in the body can alter its response due to variety of causative factors including diet, environment, life- style, infection and like. The disease prevention, health promotion or Ayurvedic therapeutics revolves around all the strategies of obtaining back the original balance of the basic elements by manipulations of materials and procedures so as to remove imbalance of Tri-Dosha and attain the original stable constitution.

Ethnopharmacology in Homeopathy

Homeopathy is a system of alternative medicine that was developed in Germany in the late 18th century. It is based on the "like cures like" principle, which means that a substance that causes symptoms in a healthy person can be used to treat similar symptoms in a sick person. Homeopathic medicines are often made from natural substances, including plants, animals and minerals, and are highly diluted. The study of ethnopharmacology in homeopathy involves identifying and analyzing the therapeutic properties of natural substances used in homeopathic medicines. Many of these substances have been used in traditional medicine, including Ayurveda and traditional Chinese medicine, for centuries. The use of natural substances in homeopathy is based on the idea that they contain a "life force" that can stimulate the body's healing processes.

There is scientific evidence to support the use of homeopathic remedies for certain conditions such as allergies and respiratory infections. However, there is also controversy about the safety and effectiveness of homeopathic medicines, especially in cases where they are used as a substitute for conventional medical treatments. Despite these controversies, the study of homeopathic ethnopharmacology provides a valuable source of information for drug discovery and development. Many of the natural substances used in homeopathy have potential therapeutic properties that can be further investigated through scientific research. Integrating traditional medical practices such as homeopathy into modern healthcare systems can also improve patient access to safe and effective treatment. In general, the study of homeopathic ethnopharmacology emphasizes the importance of exploring the potential of natural substances in drug discovery and development, while emphasizing the need for rigorous research and the responsible use of traditional medicinal practices.

Ethnopharmacology in Herbal Medicine

Herbal medicine is the use of plants or plant extracts for medicinal purposes. It has been practiced in traditional medical systems around the world for thousands of years and continues to be an important source of health care for millions of people. The study of ethanol pharmacology of herbal medicines involves the identification and analysis of medicinal properties of plants used in traditional medicine. Many of the most commonly used drugs in the world, such as aspirin, digoxin, and morphine, were originally derived from plants. The use of herbal medicines in modern medicine has also led to the development of new medicines and therapies. For example, artemisinin, a drug used to treat malaria, comes from the plant Artemisia annua, which has been used in traditional Chinese medicine for centuries. The study of ethanol pharmacology of herbal medicines involves identifying the active compounds of plants and understanding their functions in the body. For example, hypericin, a compound found in the herb, has been found to have antidepressant properties. Other herbs, such as echinacea and garlic, have been found to have immune-boosting properties. Despite the potential benefits of herbal medicines, there are also concerns about their safety and effectiveness. Some herbal preparations may interact adversely with other medications or cause adverse effects in certain individuals. Therefore, it is important that herbal medicines are thoroughly researched to determine their safety and efficacy and to ensure their responsible and effective use. Overall, research on the ethanol pharmacology of herbal medicines provides a valuable source of information for drug discovery and development and highlights the importance of integrating traditional medicinal practices into modern health systems. By understanding the medicinal properties of plants used in traditional medicine, scientists can develop new medicines and treatments that are safe, effective and accessible to people around the world.

Ethanomharmacology in Allopathy

Allopathy, also known as modern or Western medicine, is medicine based on the use of drugs, surgery and other medical procedures to treat disease. The study of ethnopharmacology in allopathy involves the identification and analysis of natural substances that can be used to develop new drugs or therapies. Many drugs used in modern medicine are derived from natural sources, including plants, animals and minerals. For example, digitalis, a drug used to treat heart failure, comes from the leaves of the foxglove plant. Paclitaxel, a drug used to treat cancer, is derived from the bark of the Pacific yew tree. Ethnopharmacology research in allopathy involves identifying natural substances with potential medicinal properties and then testing them in the laboratory to determine their efficacy and safety. For example, curcumin, found in turmeric, has been found to have anti-inflammatory and antioxidant properties and is being studied as a potential treatment for a number of diseases, including cancer, Alzheimer's and arthritis. Integrating natural substances into modern medicine can improve patient access to safe and effective treatments as well as lead to the development of new drugs and therapies. However, it is important to conduct rigorous scientific research on natural substances to ensure their safety and efficacy, and to ensure their responsible and effective use. Overall, research on the ethnopharmacology of allopathy provides a valuable source of information for drug design and development and highlights the importance of integrating traditional medical practices into modern health systems. By identifying natural substances with therapeutic properties, researchers can develop new medicines and treatments that are safe, effective and accessible to people around the world.

Ethnopharmacology in Nutraceuticals

Nutraceuticals are products derived from food that have potential health benefits in addition to basic nutrition. The study of ethanol pharmacology of foods studies and analyzes natural substances found in foods that can be used to promote health and prevent disease. Natural substances found in many foods such as fruits, vegetables and herbs have been found to have health benefits. For example, resveratrol, a compound found in grapes and red wine, has been found to have antioxidant and anti-inflammatory properties and is being studied for its potential role in preventing heart disease and cancer. Action-pharmacology research involves identifying natural substances in foods that have potential health benefits and then conducting research to determine their effectiveness and safety. For example, the glucosamine compound found in shellfish is used as a dietary supplement to treat osteoarthritis. However, some studies have shown that it may not be effective for all people and may have potential side effects. Overall, studies on the ethnopharmacology of foods provide a valuable source of information for the development of safe and effective dietary supplements. However, it is important to conduct rigorous scientific research on natural substances to ensure their safety and efficacy, and to ensure their responsileb and effective use.

Conclusion

Ethnopharmacology is a discipline that studies the traditional medicinal practices of different cultures and the use of these herbal medicines in the treatment of diseases. This includes understanding the cultural, ecological and biological factors that influence the use of medicinal plants in different societies. Ethnopharmacology has played a key role in the identification of new drugs and therapeutic agents, and its contribution to natural product discovery has been significant. For example, several important drugs such as morphine, quinine and aspirin are derived from plants traditionally used by indigenous peoples. In addition, the study of ethnopharmacology has helped preserve traditional knowledge and biodiversity. It also emphasized the importance of preserving traditional medicinal practices and promoted the development of sustainable practices in the use of medicinal plants. Overall, ethnopharmacology is an important discipline in drug development and has significant potential for identifying new drugs from natural sources. It also promotes cultural understanding and appreciation and helps preserve traditional knowledge and biodiversity.

Source of Funding

None.

Conflict of Interest

None.



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Article type

Editorial


Article page

45-48


Authors Details

Amit Gajanan Nerkar, Rushikesh P. Nagarkar


Article History

Received : 16-04-2023

Accepted : 26-05-2023


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